162
Views
3
CrossRef citations to date
0
Altmetric
Research Article

A comprehensive evaluation of the toxicology of the “Deli” cast sheet process used in experimental cigarettes

, &
Pages 64-68 | Received 18 Sep 2013, Accepted 08 Oct 2013, Published online: 17 Dec 2013
 

Abstract

Context: Manufacture of cigarettes results in tobacco by-products, some of which can be processed and added back to cigarettes. Such additions (known as reconstituted tobacco or reconstituted leaf) have been shown to reduce tar yields. A new process (termed “Deli” cast sheet) is a potential refinement of the reconstitution process.

Objective: Compare toxicity of smoke from experimental cigarettes made with reconstituted leaf with that from cigarettes made with Deli cast sheet.

Materials and methods: Analytical chemistry, Salmonella mutagenicity and cytotoxicity assays were used to evaluate the composition biological activity of mainstream smoke from experimental cigarettes made with Deli cast sheet or with reconstituted leaf. The effect of different amounts of guar and propylene glycol in Deli cast sheet was also evaluated.

Results: Small increases in the amount of nitrogen oxides were found as a result of inclusion of the Deli cast sheet when compared with reconstituted leaf; no differences in cytotoxicity or mutagenicity were found.

Conclusion: The Deli process neither significantly modified chemical composition of smoke nor affected its biological activity, as measured by the mutagenicity and cytotoxicity assays used here.

Acknowledgements

The authors acknowledge the editorial assistance of Eileen Y. Ivasauskas of Accuwrit Inc. The authors thank Lonnie T. Rimmer for his work in preparing the Supplementary Material available at http://informahealthcare.com/iht.

Supplementary material available online at:

http://informahealthcare.com/iht (Doi: 10.3109/08958378.2013.854435)

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 389.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.