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Inhalation Toxicology
International Forum for Respiratory Research
Volume 26, 2014 - Issue 8
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Research Article

Inhalation carcinogenicity of dichloromethane in rats and mice

Shigetoshi AisoJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapanCorrespondence[email protected]
,
Makoto TakeJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapan
,
Tatsuya KasaiJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapan
,
Hideki SenohJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapan
,
Yumi UmedaJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapan
,
Michiharu MatsumotoJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapan
&
Shoji FukushimaJapan Bioassay Research Center, Japan Industrial Safety and Health Association KanagawaJapan
 show all
Pages 435-451 | Received 11 Feb 2014, Accepted 13 Mar 2014, Published online: 09 Jun 2014
 
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Abstract

The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar–alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.

Acknowledgements

The present study was contracted by the Ministry of Health, Labour and Welfare, Japan.

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