Intrathecal Synthesis of Immunoglobulins in Patients with Unexplained Intermediate Uveitis

Abstract

Purpose: To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU).

Methods: Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI.

Results: Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index.

Conclusion: Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.

KEYWORDS::

• intermediate uveitis
• multiple sclerosis
• lumbar puncture

ACKNOWLEDGMENT

This study was performed at Hospices Civils de Lyon, Lyon, France.

Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.