Proinflammatory Cytokines Induce XFG Development

ABSTRACT

Purpose: To reveal the roles of proinflammatory cytokines within the process of pseudoexfoliation (PEX) production.

Methods: Our study included 120 patients referred to cataract surgery (early and late stage of pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and control group). Serum and humor levels of cytokines were measured in a sample with high sensitivity enzyme-linked immunosorbent assay (ELISA) kit.

Results: Our findings revealed that TNF-α and IL-17, overlooked by IL-6 action in the early stage and in the phase of glaucoma, played the main role in the inflammation activation in the tissue in the early and late stage of XFS and in XFG.

Conclusions: Local conditions cause chronic inflammation in the eye, subsequently activating fibrotic process with fibrotic tissue deposits in the eye.

Keywords:

• Cytokines
• inflammation
• pseudoexfoliation
• XFG
• XFS

ACKNOWLEDGMENT

We would like to thank Marija Zdravkovic for language revision of the article.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.