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Gynecological Endocrinology Volume 28, 2012 - Issue 6
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Hypothalamic Amenorrhea

Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss

Ryo TsutsumiDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
,
Akihisa FujimotoDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, JapanCorrespondence[email protected]
,
Yutaka OsugaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
,
Miyuki HaradaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
,
Yuri TakemuraDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
,
Minako KoizumiDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
,
Tetsu YanoDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
&
Yuji TaketaniDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
 show all
Pages 460-462 | Received 19 Feb 2011, Accepted 10 Oct 2011, Published online: 21 Nov 2011
 
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Abstract

We describe successful ovulation induction with low-dose hCG administration in addition to hMG in a patient with refractory hypothalamic amenorrhea. A 24-year-old woman with weight loss-related amenorrhea underwent ovulation induction and intracytoplasmic sperm injection (ICSI). Administration of exogenous gonadotropins was ineffective in ovulation induction. Supplementation with low-dose hCG in order to increase luteinizing hormone (LH) activity in the late follicular phase produced late folliculogenesis and steroidogenesis, and ovulation was then successfully induced. This report reacknowledges the critical role that LH plays cooperatively with follicle-stimulating hormone in both folliculogenesis and steroidogenesis.

Declaration of Interest: The authors declare no conflicts of interest.

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