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Gynecological Endocrinology Volume 28, 2012 - Issue sup1
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Review Article

Neuroendocrinology and ovarian aging

Luigi DevotoInstituto de Investigaciones Materno Infantil (IDIMI), Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, ChileCorrespondence[email protected]
,
Alberto PalominoInstituto de Investigaciones Materno Infantil (IDIMI), Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, Chile
,
Pablo CéspedesInstituto de Investigaciones Materno Infantil (IDIMI), Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, Chile
&
Paulina KohenInstituto de Investigaciones Materno Infantil (IDIMI), Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, Chile
Pages 14-17 | Published online: 07 Mar 2012
 
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Abstract

The ovarian aging, a dynamic process that precedes the clinical manifestations of menopause, can be assessed using ovarian reserve biomarkers. It is well-known that reproduction during the later years of reproductive life has known limitations that challenge the success of assisted reproduction. Therefore, a review of the neuroendocrine modifications during this critical period of reproductive life may help to elucidate the ovarian aging process and its impact on reproduction. In this review, we aim to further the discussion of neuroendocrine changes taking place during the ovarian aging process that may impact reproductive function.

Declaration of interest: Supported by the Chilean Research Council. Conicyt. FONDAP -Centro Estudios Moleculares de la Célula. Grant # 15010006.

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