![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Objective: The objective of the present study was to evaluate the levels of leptin, ghrelin, interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in peritoneal fluid in patients with endometriosis and infertility, and study their correlation.
Design and setting: This cross-sectional study included women undergoing diagnostic and/or therapeutic laparoscopy for endometriosis with chief complaint of infertility and/or pain at a tertiary care hospital. Based upon laparoscopic and histopathological findings, patients were categorized as with endometriosis and no endometriosis. Of the 50 patients with infertility (age 23–41 years), 19 had endometriosis while 31 had no endometriosis. The markers were assessed using ELISA kits.
Results: The median levels of leptin in patients with endometriosis (10.20 ng/mL) were higher (p = 0.04) and median levels of ghrelin in patients with endometriosis (150.4 pg/mL) were lower (p = 0.037) versus patients with no endometriosis (5.07 ng/mL and 229.6 pg/mL, respectively). The median levels of IL-6 and VEGF in patients with endometriosis were not different between the groups. The correlation analyses showed that leptin levels and IL-6 were positively correlated (p = 0.0001).
Conclusions: The results suggest that ghrelin and leptin might play a key role in pathophysiology of endometriosis, and leptin is associated with inflammation in endometriosis.
Chinese abstract
目的：本研究的目的是测定子宫内膜异位症合并不孕患者瘦素，生长激素释放肽，白介素-6（IL-6）和血管内皮生长因子（VEGF）的水平，并研究它们的相关性。
设计：横断面研究纳入了那些因不孕和/或疼痛为主诉而在三级医院行诊断和/或治疗性腹腔镜手术的子宫内膜异位症不孕患者。根据腹腔镜手术及病理组织学结果，患者被分为子宫内膜异位症患者和非子宫内膜异位症患者。50例不孕患者（年龄23-41岁）中，19例有子宫内膜异位症，而31没有子宫内膜异位症。该标记用ELISA试剂盒。
结果：与非子宫内膜异位患者瘦素和生长素水平（分别5.07 ng / mL和229.6皮克/毫升）相比，子宫内膜异位患者瘦素的平均水平（10.20毫微克/毫升）较高（P = 0.04），生长素平均水平（150.4皮克/毫升）较低（P = 0.037）。而IL-6和VEGF的平均水平两组之间无明显差异。相关分析表明，瘦素与IL-6呈正相关（P = 0.0001）。
结论：研究结果显示，生长激素释放肽和瘦素可能在子宫内膜异位症的病理生理中发挥关键作用，瘦素与子宫内膜异位症炎症相关。