High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS)

Abstract

C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman–Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects.

Chinese abstract

C反应蛋白（CRP）是2型糖尿病和心血管疾病的危险因素。对于多囊卵巢综合征（PCOS），尤其是印度女性，在高敏C反应蛋白（hs-CRP）水平及其与PCOS的各项组分的关系方面，可查到的数据很有限。本研究的目的是监测患或不患PCOS的青春期女性的血清hs-CRP浓度，评估印度女性的血清hs-CRP浓度与PCOS指标间可能的相关性。160名PCOS患者和60名有正常月经周期的非PCOS女性参与了本试验。临床评价包括人体测量，Ferriman–Gallwey（FG）评分和血压（BP）测量。实验室测定指标包括T4，TSH， LH,，FSH，总睾酮，催乳素，皮质醇，17-OHP，hs-CRP，血脂，胰岛素的测量和2h口服葡萄糖耐量试验。同时测量稳态模式评估胰岛素抵抗指数（HOMA-IR），定量胰岛素敏感性检测指数（QUICKI）以及葡萄糖耐量。PCOS患者与正常女性的FG得分，LH,，FSH，HOMA-IR，QUICKI存在显著不同（p<0.01），尽管PCOS患者的hs-CRP水平有增高的趋势，但两组并无显著差别（p>0.05)。在PCOS组还发现hs-CRP与体重指数（BMI）有显著正相关（r=0.308, p<0.01）。该结果表明，hs-CRP水平与PCOS也许无关联性，而可能与该课题中的子项目即体重相关。

• Body mass index
• Ferriman–Gallwey score
• HOMA-IR
• hs C-reactive protein
• insulin resistance
• obesity
• polycystic ovary syndrome
• testosterone

Acknowledgements

The author(s) thank all participants and staff for their co-operation and valuable support.