Relief of uterine bleeding by cyclic administration of dienogest for endometriosis

Abstract

Objective: This study assessed the relief of uterine bleeding and clinical symptoms during cyclic administration of dienogest for the treatment of endometriosis.

Methods: In total, 25 patients undergoing ovarian cyst enucleation and given dienogest participated in this study. Dienogest 2 mg/day was administered for 3 weeks, and the drug was then withdrawn for 1 week (cyclic administration of dienogest). This 4-week cycle was repeated six times. Patients’ records were prospectively analyzed for the number of days on which any uterine bleeding occurred, as well as menstrual pain before and after the start of dienogest administration were evaluated with a view to using the data obtained herein as the basis.

Results: During the period of cyclic administration of dienogest, uterine bleeding occurred on 5.8 to 7.7 days per 4-week period on an average through cycles. Of uterine bleeding episodes, menstruation-like uterine bleeding was present in about 80% of patients. The visual analog scale (VAS) value for menstrual pain significantly decreased from 3.8 before dienogest administration after surgery to 1.5 at the completion of cycle 1, VAS remained low thereafter.

Conclusion: These results raise the possibility that cyclic administration of dienogest may relieve lessen uterine bleeding, a major adverse event and menstrual pain.

Chinese abstract

目的：本研究评估周期应用地诺孕素治疗子宫内膜异位症时子宫出血和临床症状缓解的情况。

方法：共有25例进行了卵巢囊肿摘除术并给予地诺孕素的患者参与了此项研究。地诺孕素2 mg /天，给药3周，然后停药1周（周期应用地诺孕素）。这样4周一个周期，重复六次。记录患者的数据进行前瞻性的分析：包括对任一发生子宫出血的天数，评估用地诺孕素前后的月经疼痛情况。结果：周期应用地诺孕素期间，以每4周的时间作为平均周期，子宫出血发生为5.8到7.7天。子宫出血的发生，像月经的子宫出血发生在大约80%的患者。痛经的视觉模拟量表（VAS）值从术后用地诺孕素前的3.8明显的减少为第一周期结束后的1.5，此后VAS仍然很低。结论：这些结果表明，周期性应用地诺孕素可能可以缓少子宫出血，这是一个主要的不良事件并且减轻痛经。

• Cyclic administration
• dienogest
• drug adherence
• endometriosis
• lessen uterine bleeding