Serum anti-Müllerian hormone and insulin resistance in the main phenotypes of non-obese polycystic ovarian syndrome women in China

Abstract

Objectives: Objective was to evaluate anti-Müllerian-hormone (AMH) and parameters for insulin resistance (IR) in the main phenotypes of polycystic ovarian syndrome (PCOS), and to investigate their correlation for the first time in non-obese Chinese women.

Methods: Within this prospective study, 160 PCOS cases and 40 healthy women, matched by age and BMI, were included. In four groups (n = 40) according to the four phenotypes of PCOS by definition of the National Institute of Health (2012), AMH, ovarian volume and number of follicles 2–9 mm were assessed as well as insulin resistance indexes (Homeostatic Model Assessment) (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI).

Results: AMH levels were higher in PCOS than in controls, with differences comparing the phenotypes, highest in the group with all three criteria for PCOS. However, for HOMA-IR and QUICKI and correlation to AMH no significant differences were found.

Conclusions: AMH is a useful parameter to assess in the different phenotypes the severity of PCOS, and to compare with healthy women, for the first time demonstrated in Chinese patients. In contrast, the parameters for IR and their relation to AMH did not show clear differences comparing the four phenotypes, and need further investigation.

Chinese abstract

目的 首次评估中国非肥胖妇女多囊卵巢综合征的主要表型（PCOS）中抗苗勒管激素（AMH）和胰岛素抵抗参数（IR，并且探讨它们的相关性。

方法 这项前瞻性研究包括了160例PCOS患者和40名健康女性，年龄和体重指数均匹配。根据美国国立卫生研究院所定义的多囊卵巢的4个主要表型分成了4组（n=40），分别对AMH，卵巢体积和2-9mm的卵泡数目以及胰岛素抵抗指数（稳态模型）（HOMA-IR）和定量胰岛素敏感性检测指数（QUICKI）进行了评估。

结果 PCOS组的抗苗勒氏管激素水平高于对照组,不同表型存在差异，其中最高组高出三个标准差，然而,对于HOMA-IR QUICKI和相关抗苗勒氏管激素没有发现显著差异。

结论 AMH是一个有用的参数，可以评估不同表型多囊卵巢综合征的严重程度，并与健康妇女比较，这是首次在中国患者中论证。与此相反，胰岛素抵抗及其与AMH的相关性，四个表型并没有表现出显著差异，需要进一步的研究。

• Anti-Müllerian hormone
• insulin resistance
• polycystic ovarian syndrome