Endogenous thrombin potential in polycystic ovary syndrome: the association to body mass index, insulin resistance, and inflammation

Abstract

Objectives: The objective of this study is to investigate plasma endogenous thrombin generation in four different phenotypes of polycystic ovary syndrome (PCOS) defined by Body Mass Index (BMI) and insulin resistance (IR). PCOS is diagnosed according to the Rotterdam criteria.

Design: Multicenter cross-sectional study.

Setting: Two major University Hospitals in the Capital region of Denmark.

Patients: Hundred forty-eight European women with PCOS were consecutively recruited during April 2010–February 2012. Clinical examination, blood sampling, and DEXA scan were performed.

Main outcome measures: Endogenous thrombin potential (ETP).

Results: PCOS women with phenotype BMI > 25 + IR have increased potential of thrombin generation. ETP is associated with total body fat mass, IR, and CRP.

Conclusions: Obese and insulin resistant women with PCOS have elevated level of ETP corresponding to increased risk of CVD. ETP is related to well-known CVD risk factors in PCOS but not in general to the Rotterdam criteria.

Chinese abstract

目的：本研究旨在探究四种不同表型的多囊卵巢综合征（PCOS）的血浆内源性凝血酶生成潜能，四种表型依据体重指数（BMI）和胰岛素抵抗（IR）判定。PCOS依据鹿特丹标准诊断。

研究设计：多中心横断面研究

研究地点：丹麦首都地区两所大学附属医院

患者：自2010年4月至2012年12月连续招募148名欧洲PCOS女性。进行临床检查、血样和DEXA扫描。

主要观察指标：内源性凝血酶生成潜能（ETP）

结果：PCOS患者表型为BMI＞25 + IR者凝血酶生成潜能增加。ETP与总体重指数、IR和CRP相关。

结论：肥胖和胰岛素抵抗的PCOS女性ETP水平增高，相应的CVD风险增高。ETP与PCOS的已知CVD风险因素相关，但一般并不与鹿特丹标准相关。

• Endogenous thrombin generation
• inflammation
• insulin resistance
• obesity
• PCOS

Declaration of interest

The authors report that they have no conflicts of interest. The study was supported by The Research Fund of Region Zealand; The local Research Committee, Herlev University Hospital; Department of Gynaecology and Obstetrics, Herlev University Hospital; Merck Serono; Snedkermester Sophus Jacobsen and wife Astrid Jacobsen’s foundation.