1-h Postprandial glucose level is related to the serum anti-Müllerian hormone level in women with polycystic ovary syndrome

Abstract

The aim of this study was to evaluate the relationship between the serum anti-Müllerian hormone (AMH) level and parameters related to insulin resistance in Korean women with polycystic ovary syndrome (PCOS). A total of 95 Korean women aged 18–33 years who were newly diagnosed with PCOS according to the Rotterdam Consensus at a university hospital were included in this study. Blood samples were collected from all participants during the early follicular phase using tubes without anticoagulants after an overnight fasting to determine the serum AMH level and other biochemical parameters, and then a standard 2-h 75-g oral glucose tolerance test (OGTT) was performed for all participants. All patients with PCOS were divided into two groups based on the serum AMH level: group 1 (AMH < 10.0 ng/ml) and group 2 (AMH ≥ 10.0 ng/ml). The clinical variables were not significantly different between the two groups. The mean postprandial glucose level at 1 h (PPG1) in group 1 (111.70 ± 4.9 mg/dl) was significantly lower than that in group 2 (136.76 ± 9.86 mg/dl). No significant differences between the two groups were found in the other insulin resistance-related parameters. In conclusion, the serum AMH level may be related to PPG1 in women with PCOS.

Chinese abstract

本研究目的是探讨韩国多囊卵巢综合征妇女血清抗苗勒氏管激素水平和胰岛素抵抗相关参数（指标）之间的关系。总共95名18-33岁的韩国妇女纳入本研究，这些妇女最近在大学附属医院被诊断为多囊卵巢综合征，诊断依据是鹿特丹标准。所有受试者血液标本都在早卵泡期采集，在禁食一整夜后用加抗凝剂的试管采集标本来测定血清AMH水平和其他生化指标，之后所有受试者都接受标准的2小时的75克葡萄糖耐量试验（OGTT）。根据血清AMH水平，所有受试者被分为2组，第一组(AMH<10.0 ng/ml)和第二组(AMH≥10.0 ng/ml).两组间的临床表现没有明显差异。第一组平均餐后1小时血糖水平(PPG1)（111.70 ± 4.9 mg/dl）明显低于第二组(136.76 ± 9.86 mg/dl)。两组之间其他胰岛素抵抗相关指标没有明显差异。得出结论，多囊卵巢综合征妇女血清抗苗勒氏管激素水平可能和餐后一小时血糖水平相关。

• Anti-Müllerian hormone
• insulin resistance
• oral glucose tolerance test
• polycystic ovary syndrome
• postprandial glucose

Declaration of interest

The author reports no declaration of interest.