Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding

Abstract

Purpose: We aimed to investigate the association of metabolic syndrome and metabolic risk factors with endometrial hyperplasia and carcinoma among women with abnormal uterine bleeding (AUB).

Methods: This study included 199 patients who had undergone endometrial curettage due to abnormal uterine bleeding. We divided the patients into two groups according to whether they had an abnormal (n = 53) or normal endometrium (n = 146). Waist circumference, blood pressure, fasting glucose and serum lipid levels were measured and statistically analyzed. The women in each group were matched with regard to mean age, gravidity, parity and menopausal status.

Results: We found increased prevalence of metabolic syndrome, diabetes, general and abdominal obesity, hypertension, elevated levels of glucose, total cholesterol and LDL-cholesterol and reduced levels of HDL-cholesterol among women with endometrial carcinoma and hyperplasia. These results were detected particularly in postmenopausal (>50 years) women compared to pre-menopausal cases (<50 years). All metabolic parameters were similar between hyperplasia and cancer groups.

Conclusion: Metabolic syndrome and its components have been shown to have profound impacts on initiation and progession of endometrial pathology, particularly during post-menopausal period.

Chinese abstract

目的：我们的目的是探讨在异常子宫出血（AUB）的女性中代谢综合征、代谢危险因素与子宫内膜增生、子宫内膜癌的关联。

方法：本研究纳入了199名因异常子宫出血而行子宫内膜诊刮术的患者。我们根据子宫内膜是否正常将患者分为正常组（n=146）和异常组（n=53）。测量腰围、血压、空腹血糖和血脂水平并进行统计学分析。两组女性的平均年龄、妊娠及月经状况是相匹配的。

结果：我们发现子宫内膜癌和子宫内膜增生的女性更可能出现代谢综合征，糖尿病，一般性和腹型肥胖，高血压，高血糖，总胆固醇和低密度脂蛋白胆固醇水平升高以及高密度脂蛋白胆固醇降低。与绝经前女性（小于50岁）相比较，绝经后女性（大于50岁）更容易出现上述情况。在子宫内膜增生组和癌症组，所有的代谢参数是相似的。

结论：代谢综合征和其所包含的异常代谢情况被证实对子宫内膜病理的发生和发展具有重要影响，尤其是绝经以后。

• Endometrium
• metabolic syndrome
• pathology
• uterine bleeding

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.