302
Views
21
CrossRef citations to date
0
Altmetric
Hashimoto Thyroiditis and Ovarian Reserve

Assessment of ovarian reserve in euthyroid adolescents with Hashimoto thyroiditis

, , &
Pages 306-310 | Received 22 Sep 2015, Accepted 02 Nov 2015, Published online: 26 Nov 2015
 

Abstract

Aim: We aimed to investigate the ovarian function and reserve in euthyroid adolescents (TSH < 2.5 mIU/L) diagnosed with Hashimoto thyroiditis (HT).

Methods: This case-control study included 30 adolescent girls (mean age 15.1 ± 1.4 years) newly diagnosed as HT with presence of high thyroid antibodies with gland heterogeneity in ultrasound and age-matched 30 healthy female subjects. Anti-ovarian antibody (AOAb), LH/FSH ratio, estradiol, anti-mullerian hormone (AMH), inhibin-B, total testosterone, antral follicle count, ovarian volumes and uterine length were measured. The clinical, laboratory, and ultrasound data of the HT and control groups were compared.

Results: There were no significant differences between the girls with HT and healthy controls in relation to LH/FSH ratio, estradiol and inhibin-B levels. AOAb (p = 0.02), AMH (p = 0.007) and total testosterone levels were higher in HT group than the control group (p = 0.03). AOAb level was found to be positively correlated with LH/FSH ratio (p = 0.03), AMH (p = 0.01) and inhibin-B (p < 0.001) in HT group.

Conclusion: This study demonstrated that the adolescent girls diagnosed with autoimmune thyroiditis had normal ovarian reserve based on measurements of AMH, inhibin B, FSH, LH/FSH ratio, estradiol and antral follicle counts.

Chinese abstract

目的:

我们的目的是调查甲状腺功能正常(TSH<2.5 mIU/L)的桥本甲状腺炎青年患者的卵巢功能及储备。

方法:

这项病例对照研究包括30例青春期女性(平均年龄15.1±1.4)初诊为桥本甲状腺炎的患者,表现为高甲状腺抗体,超声表现为异质性。对照组为30例同年龄的健康女性。分别检测抗卵巢抗体、LH/FSH比值、雌激素、抗苗勒氏管激素、抑制素B、总睾酮、窦卵泡数、卵巢体积、子宫长度。比较桥本甲状腺炎组和对照组的临床、实验及超声数据。

结果:

桥本甲状腺炎组和正常对照组在LH/FSH的比值、雌激素含氯及抑制素B的水平上没有显著性差异。桥本甲状腺炎组的抗卵巢抗体(p=0.02),抗苗勒氏管激素(p=0.007)和雌激素总量的水平高于正常对照组(p=0.03)。抗卵巢激素被发现和LH/FSH的比值及抗苗勒氏管激素、抑制素相关。

结论:

项研究表明:青春期女性诊断为自身免疫性甲状腺炎可以通过检测抗苗勒氏管激素、抑制素B ,FSH、LH/FSH比值、雌激素及窦卵泡数量评估其正常的卵巢功能储备。

Declaration of interest

We do not have any financial and personal relationships with other people or organizations. The authors do not have any conflict of interest to disclose.

No financial assistance was received in support of the study.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access
  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart
* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.