Successful use of “Hour 1” transfer of sperm microinjected oocytes in natural cycles of poor responder women: a prospective randomized controlled pilot study

Abstract

The aim of the study is to demonstrate the successful use of “Hour 1” transfer of sperm microinjected oocytes in natural cycles of poor responder women. Seventy women were selected from 92 consecutive poor responders undergoing intracytoplasmatic sperm injection (ICSI) in a natural cycle at our Sterility and Assisted Reproduction Unit from September 2009 to July 2013, and randomly distributed in two homogeneous groups: Group A or B. Women in Group A (35) underwent transfer within 1 h after ICSI; Group B (35, control group) underwent transfer 3 days after ICSI. In Group A, seven clinical pregnancy and one miscarriage occurred; in Group B, eight clinical pregnancies and two miscarriages were observed. Pregnancy, miscarriage, term pregnancy and overall live birth rates’ difference between the two groups was not statistically significant (p > 0.05). Difference between the two groups in terms of timing, type of delivery and newborn birthweight was not observed. Neither ectopic pregnancy nor multiple pregnancies occurred. “Hour 1” uterine transfer of ICSI oocytes, still to be considered with caution because of the relatively low number of observations of the pilot study, deserves further attention on a larger scale, and might be evaluated for clinical and financial effectiveness in other clinical settings.

Chinese abstract

这个研究的目的是证明低反应妇女自然周期卵胞浆内单精子显微注射后“1小时”移胚的成功应用. 从2009年9月至2013年7月于我院不孕及辅助生殖科行卵胞浆内单精子显微注射（ICSI）的92例连续患者中挑选70例。随机平均分为两组：A组或者B组。A组患者（35）ICSI后一小时内移植胚胎；B组患者（35，对照组）ICSI后三天移植胚胎。A组中有7例临床妊娠和1例流产。在B组中有8例临床妊娠和2例流产。妊娠、流产、足月妊娠和整体活产率两组没有统计学差异。两组分娩时间、分娩方式和出生体重无明显差异。未发生异位妊娠和多胎妊娠。卵胞浆内单精子显微注射后“1小时”移植胚胎仍然需要谨慎，因为初步性研究观察的人数相对较少，进一步更大规模的研究值得关注，以评估其他临床应用的临床效果和经济效益。

• “Hour 1” transfer
• ICSI
• natural cycle
• poor responder