Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis

Abstract

Adenomyosis is a prevalent gynecologic benign disease in women. Despite its significance, there is only a limited understanding of its pathological mechanisms. Talin1, a cytoskeletal protein, plays an important role in cell survival, proliferation, invasion and migration. The objective of this study was to investigate the mRNA and protein expression of talin1 in both the eutopic and ectopic endometria of women with adenomyosis. Higher talin1 mRNA levels were observed in both ectopic and eutopic endometria from the adenomyosis subjects compared with the eutopic endometria from women without adenomyosis. Immunohistochemistry revealed increased epithelial expression of talin1 in the ectopic and eutopic endometria from patients with adenomyosis compared with those without adenomyosis. When tests were performed on matched samples of eutopic and ectopic endometria of adenomyosis subjects, the mRNA and protein expression of talin1 was much higher in the ectopic endometria than in the eutopic endometria. The results reveal that the expression pattern of talin1 in the eutopic and ectopic endometria is enhanced in women with adenomyosis. Increased talin1 expression may play a role in the pathogenesis and development of adenomyosis.

Chinese abstract

子宫肌腺症是一种常见的妇科良性疾病。虽然该病很重要，但是对其发病机制了解有限。Talin1一种细胞骨架蛋白质，在细胞生存、增殖，入侵和迁移方面扮演重要的角色。本研究的目的是探究子宫肌腺症妇女正常和异位子宫内膜Talin1 mRNA水平及蛋白质的表达。子宫肌腺症妇女正常位置或异常位置的子宫内膜Talin1 mRNA水平明显高于无子宫肌腺症妇女正常位置的子宫内膜的Talin1 mRNA水平。免疫组织化学也显示，与无子宫肌腺症妇女相比，内异症患者在正常位置或异常位置的子宫内膜Talin1上皮表达增加，当配对检测子宫肌腺症患者正常位置及异常位置的子宫内膜时，发现Talin1及其mRNA的表达异常位置比正常位置内膜高出很多。研究结果表明，子宫肌腺症患者正常位置及异位的子宫内膜talin1的表达均增强。talin1的过表达可能在子宫肌腺症的发病机理及发展中发挥作用。

• Adenomyosis
• endometrium
• talin1

Declaration of interest

The authors report no conflicts of interests.