IGF-1 is associated with fetal growth and preterm delivery in type 1 diabetic pregnancy

Abstract

Aim: No data on IGF-1 and either preterm or preeclampsia have been reported so far in diabetic pregnancies. We evaluated consecutive measurements of IGF-1 for preeclampsia, preterm delivery and birth weight in type 1 diabetic pregnancy.

Setting: In an outpatient university clinic, 97 pregnant women were consecutively recruited for evaluation of indicators for deterioration of diabetes status and adverse perinatal outcome. At every visit, a blood sample for measurement of IGF-1 was drawn.

Results: IGF-1 levels from week 14 to 32 was consistently lower in women who delivered preterm compared with women whose delivered after gestational week 36; the increase in 2nd and 3rd trimester was steeper in those delivering at term than in women delivering preterm (p = 0.032). IGF-1 in preeclampsia did not show the same relation in diabetic women (p = 0.74). The lowest tertile of birth weight ratio (0.8–1.2) was associated with lower IGF-1 from week 14 to 32 (p = 0.047, adjusted for preterm delivery and preeclampsia).

Conclusion: We found low IGF-1 levels associated with preterm delivery and low birth weight.

Chinese abstract

目的：糖尿病孕妇中，迄今尚没有IGF – 1与早产或子痫前期关系的相关数据报道。我们连续测量1型糖尿病孕妇在子痫前期和早产的IGF-1水平以及新生儿出生体重。

背景：在某大学门诊部，连续招募了97名孕妇评价糖尿病恶化指标和不良围产期结果。

在每一次检查中，测量血液样本的IGF – 1水平。

结果：与妊娠36周后生产的孕妇相比早产女性的IGF - 1水平在14到32周持续低水平；足月产者在孕二期和三期IGF - 1水平较早产患者升高更加明显（p = 0.032）。在糖尿病子痫前期妇女IGF-1水平没有这种关系（p = 0.74）。最低三分位出生体重比（0.8 - -1.2）与14到32周低水平的IGF-1相关（p = 0.047，依据早产和子痫前期进行校正的）。

结论：我们发现低水平IGF - 1与早产和低出生体重相关。

• Birth weight
• IGF-1
• preeclampsia
• preterm delivery
• type 1 diabetes mellitus

Declaration of interest

All authors declare no conflicts of interest.