Evaluation of cardiovascular disease risk in women with surgically induced menopause

Abstract

Objective: This study evaluates cardiovascular disease (CVD) risk among women undergoing natural menopause or surgically induced menopause through the measurement of serum growth differentiation factor-15 (GDF-15), B-type natriuretic peptide (BNP), ischemia modified albumin (IMA), total cholesterol, LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglyceride, fibrinogen, and C-reactive protein (CRP).

Materials and methods: The study included women with surgically induced menopause (n = 50) and women undergoing natural menopause (n = 50). The two study groups were matched according to age, body mass index, menopause duration. GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP were measured.

Results: There was no significant difference in GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP results between the two groups.

Conclusion: We conclude that there is no increase in CVD risk among women aged 40–50 with surgically induced menopause relative to matched control subjects undergoing normal age-related menopause.

Chinese abstract

研究目的：本研究通过检测自然绝经或手术绝经女性的血清分化生长因子—15（GDF-15），B型利钠肽（BNP），缺血修饰白蛋白（IMA）、总胆固醇、低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C），甘油三酯，纤维蛋白原以及C-反应蛋白（CRP）来评估她们的心血管病（CVD）风险。

研究对象及研究方法：该研究的对象有手术绝经的女性（n=50）和自然绝经妇女（n = 50）。这两个研究组成员间的年龄、体重指数、绝经期持续时间相匹配。测定GDF-15， BNP ，IMA、总胆固醇、LDL-C， HDL-C，甘油三酯、纤维蛋白原和CRP水平。

结果：两组GDF-15， BNP ，IMA、总胆固醇、LDL-C， HDL-C，甘油三酯、纤维蛋白原和CRP水平并没有明显的差异。

结论：我们认为40 - 50岁的手术绝经女性与相匹配的自然绝经的对照组相比，其心血管病风险并没有升高。

• Cardiovascular risk
• natural menopause
• surgical menopause

Declaration of interest

The authors declare that there are no competing interests related to the article. This work was supported by a research grant 2014/A132 from Bozok University Research Fund, Yozgat 66200, Turkey.