Abstract
Objective: This study evaluates cardiovascular disease (CVD) risk among women undergoing natural menopause or surgically induced menopause through the measurement of serum growth differentiation factor-15 (GDF-15), B-type natriuretic peptide (BNP), ischemia modified albumin (IMA), total cholesterol, LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglyceride, fibrinogen, and C-reactive protein (CRP).
Materials and methods: The study included women with surgically induced menopause (n = 50) and women undergoing natural menopause (n = 50). The two study groups were matched according to age, body mass index, menopause duration. GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP were measured.
Results: There was no significant difference in GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP results between the two groups.
Conclusion: We conclude that there is no increase in CVD risk among women aged 40–50 with surgically induced menopause relative to matched control subjects undergoing normal age-related menopause.
Chinese abstract
研究目的:本研究通过检测自然绝经或手术绝经女性的血清分化生长因子—15(GDF-15),B型利钠肽(BNP),缺血修饰白蛋白(IMA)、总胆固醇、低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),甘油三酯,纤维蛋白原以及C-反应蛋白(CRP)来评估她们的心血管病(CVD)风险。
研究对象及研究方法:该研究的对象有手术绝经的女性(n=50)和自然绝经妇女(n = 50)。这两个研究组成员间的年龄、体重指数、绝经期持续时间相匹配。测定GDF-15, BNP ,IMA、总胆固醇、LDL-C, HDL-C,甘油三酯、纤维蛋白原和CRP水平。
结果:两组GDF-15, BNP ,IMA、总胆固醇、LDL-C, HDL-C,甘油三酯、纤维蛋白原和CRP水平并没有明显的差异。
结论:我们认为40 - 50岁的手术绝经女性与相匹配的自然绝经的对照组相比,其心血管病风险并没有升高。
Declaration of interest
The authors declare that there are no competing interests related to the article. This work was supported by a research grant 2014/A132 from Bozok University Research Fund, Yozgat 66200, Turkey.