Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy

Abstract

Objective: The objective was to determine the value of clinical and analytical maternal factors to predict birth weight and umbilical cord biochemical markers of diabetic fetopathy.

Methods: Prospective evaluation of gestational diabetes pregnancies (n = 50). Maternal weight-related clinical and analytical factors were collected during pregnancy. After birth, an umbilical cord sample was taken.

Results: Univariate linear regression analysis showed relationship between maternal weight, glycated hemoglobin (HbA1c) and insulin-like growth factor 1 (IGF1) with birth weight percentile. A significant association was found between maternal weight and cord insulin and C-peptide. Maternal HbA1c, leptin and insulin during pregnancy showed a positive linear association to cord leptin, insulin and C-peptide. In multivariate analysis models, final maternal BMI showed an independent positive association with cord C-peptide.

Conclusions: Maternal weight-related and analytical parameters show diagnostic value to birth weight and cord markers.

Chinese abstract

目的：研究目的是明确临床的和分析性的母体因素预测出生体重和糖尿病胎儿脐带生化标志物的价值。

方法：妊娠期糖尿病妊娠的前瞻性评估（n=50）。收集母亲孕期体重相关的临床和分析性因素。出生后采集脐血样本。

结果：单因素线性回归分析表明，母亲体重、糖化血红蛋白（HbA1c）和胰岛素样生长因子1（IGF1）与出生体重百分位数相关。发现母亲体重和脐血胰岛素及C肽之间存在显著的相关性。妊娠期间母体糖化血红蛋白、瘦素和胰岛素与脐带血瘦素、胰岛素及C肽呈线性正相关。在多变量分析模型中，母亲最终的BMI与脐带血C肽呈独立的正相关关系。

结论：母亲体重相关参数及分析性参数对出生体重及脐血标志物具有诊断意义。

• Birth weight
• C-peptide
• erythropoietin
• ferritin
• gestational diabetes
• IGF1
• leptin

Acknowledgements

The authors gratefully acknowledge Israel J Thuissard for expert technical assistance. The authors thank Cristina Criado, Maria Caballero and all the nursing staff on the Labor and Delivery Unit, who were responsible for the management of the umbilical cord sample for the present study. We also thank all the Obstetrics and Gynecology Department and Clinical Analysis Department staff for their helpful collaboration.

Declaration of interest

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors report no other conflicts of interest. This study was funded by grants for medical investigation by Fundación Mutua Madrileña (Grant No. AP105302012) and Fundación Universidad Europea de Madrid (Grant No. 2013/UEM22).