Abstract
Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF).
Materials and methods: In this study, BALB/cByJNarl (5 weeks, weighing 20–25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored.
Results: Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p < 0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice.
Conclusions: SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
This study was supported by grants from the National Science Council of Taiwan, R.O.C. (NSC 101-2320-B-038 -003 and NSC100-2320-B-038 -024).