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Abstract
Background The correlation between body iron stores and inflammation with insulin resistance in type 2 diabetes is not thoroughly investigated, especially in the Persian population.
Methods A cross-sectional study was designed in Tehran, Iran. Fifty-four people with type 2 diabetes and 53 matched healthy participants were included. Serum ferritin, total iron binding capacity, insulin resistance, C-reactive protein and tumor necrosis factor-α were measured in both groups.
Results Diabetic patients had higher insulin resistance, hemoglobin A1C and serum ferritin. Significant positive correlations were observed between insulin resistance with serum ferritin and tumor necrosis factor-α and between serum ferritin and tumor necrosis factor-α in diabetic patients.
Conclusions Inter-relationship between insulin resistance, serum ferritin and TNF-α was found in type 2 diabetic patients. Serum iron even in the normal range had positive correlation with insulin resistance. It may be because the normal ranges determined for serum ferritin are too wide and the criteria for iron overload are too high.
Acknowledgements
The authors thank all of the participants in the study for their cooperation. They would also like to thank all of the help given by the Iranian Diabetes Society.
Declaration of interest: The present work was supported by a grant from the Vice-Chancellor of Tehran University of Medical Sciences. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.