Abstract
The oxidation level of omega-3 fatty acid supplements commercialized in capsules may be a risk to consumers’ health. For this purpose, we have designed a single-blind, parallel-group, randomized controlled trial in which 52 women participated. Volunteers were randomly distributed into three groups consuming: (1) less oxidized oil pills, (2) highly oxidized oil pills and (3) no capsules. All groups consumed a fish-rich diet. Circulating glucose, total cholesterol, triglycerides and glutamic pyruvic transaminase were determined at the beginning and end (30 days) of the study. As a result, the ingestion of less oxidized ω-3 supplements reduced circulating triglyceride and cholesterol levels, as opposed to the highly oxidized omega-3 capsules, which had a negative effect on cholesterol levels. In conclusion, the level of oxidation of the supplements is a key factor in controlling circulating lipid profile. Therefore, manufacturers must pay attention to the quality of the prime product prior to encapsulation.
Acknowledgements
Authors want to thank Ma Asunción Iborra Campos for their help in sample collection in her Pharmacy.
Consort Checklist: https://sites.google.com/a/goumh.umh.es/clinicaltrials/anuncios
Trial Protocol: https://sites.google.com/a/goumh.umh.es/clinicaltrials/anuncios
Trial registration: ClinicalTrials.gov Identifier: NCT01799720