Acute recovery from exercise in people with multiple sclerosis: an exploratory study on the effect of exercise intensities

Abstract

Purpose A better understanding of how people with multiple sclerosis (pwMS) recover from exercise may help inform interventions. Methods We explored physiological and perceptual responses following exercise of different intensities, using a crossover exposure-response design, in 14 adults with multiple sclerosis (MS) and 9 controls. A cycling exercise test determined maximum capacity (Wpeak). Participants then performed 20-min exercise sessions relative to Wpeak (random order separated by 7 days): (1) 45% and (2) 60% continuous cycling and (3) 90% intermittent cycling (30 s cycling, 30 s rest). During a 45-min recovery period, tympanic temperature (Temp°C), exertion in breathing (RPEbr) and legs (RPEleg), and cortical excitability (MEParea) were measured. Results Eleven pwMS and eight controls completed the study. Controls performed better on the exercise test (p < 0.05), thus more absolute work during subsequent sessions. PwMS took longer to recover RPEleg with recovery time increasing with intensity (45%-6 min; 60%-15 min; 90%-35 min) and correlating with Temp°C. MEParea was significantly depressed in both groups at 45% and 60% (p < 0.001), in the MS group this also correlated with RPEleg. Conclusions Feelings of leg exertion may persist after exercise in some pwMS, especially at high intensities. This may relate to body temperature and, after continuous exercise, cortical excitability. These results support considering the recovery period post exercise and provide an insight into potential correlates of post-exercise fatigue.

Implications for Rehabilitation

• A better understanding of how pwMS recover following exercise may help inform exercise prescription a long side fatigue management.

• This study showed that, in pwMS, the time taken to recover from feelings of leg fatigue increased with the intensity of the exercise session rather that total work performed and was related to increase in body temperature.

• The results of this relatively small study support the need to consider a recovery period after exercise and provide an insight into potential physiological correlates

Keywords:

• Exercise
• exertion
• fatigue
• multiple sclerosis
• recovery

Acknowledgements

We would like to extend gratitude to the participants of the study and user steering groups. We would like to thank the Oxford Centre for Enablement and Prof. D Wade for supporting the study.

Disclosure statement

The authors report no conflicts of interest.

Funding Information

This work was supported by the Multiple Sclerosis Society of Great Britain and Northern Ireland [grant number 840/06]. HD is supported by the Elizabeth Casson Trust.