Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer

Abstract

In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer. The peculiar metabolism of dietary compounds of the individual microbiota complement, its overall immunostimulation and immunomodulatory activity, and eventually the production of toxins that perturb the regulation of cell growth, define the balance of positive and negative risk factors for colorectal cancer development. Moreover, shaping the composition of the human intestinal microbiota, diet has an indirect impact in determining the balance between health and disease. The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset.

Keywords::

• Intestinal microbiota
• immune system
• inflammation
• diet
• colorectal cancer

Acknowledgements

The authors are grateful to Antonella Del Brocco and Michela Di Nottia, ISS, for precious help with the editing of the manuscript.

Declaration of interest

Authors have no declarations of interest.