Actinobacterial enzyme inhibitors – A review

Abstract

Actinobacteria have potential as important new sources of enzyme inhibitors. Enzyme inhibitors have great demand in medicine, agriculture and biotechnology. In medicine, enzyme inhibitors can be used as therapeutic agents for bacterial, fungal, viral and parasitic diseases as well as treating cancer, neurodegenerative, immunological and cardiovascular diseases. Enzyme inhibitors are also valuable for the control of carbohydrate-dependent diseases such as diabetes, obesity and hyperlipidemia and melanogenesis in skin. They can be also involved in crop protection against plant pathogens, herbivorous pests and abiotic stresses such as drought. In this review, we discuss about several actinobacterial enzyme inhibitors with various industrial uses and biotechnological applications.

• Actinobacteria
• amylase inhibitors
• enzyme inhibitors
• medicine

Acknowledgements

Authors thank Prof. L. Kannan, Former Vice-chancellor of Thiruvalluvar University, for critically going through the manuscript and offering comments.

Declaration of interest

This research was supported by a grant from Marine Bioprocess Research Center of the Marine Biotechnology Program funded by the Ministry of Oceans and Fisheries, Republic of Korea. One of the authors Kannan Sivakumar expresses his thanks to the Director, Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences and Annamalai University authorities for facilities and encouragement.