Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

Abstract

A decade ago, the ability of nasal tissues to metabolize inhalants was only dimly suspected. Since then, the metabolic capacities of nasal cavity tissues has been extensively investigated in mammals, including man. Aldehyde dehydrogenases, cytochrome P-450-dependent monooxygenases, rhodanese, glutathione transferases, epoxide hydrolases, flavincontaining monooxygenases, and carboxyl esterases have all been reported to occur in substantial amounts in the nasal cavity. the contributions of these enzyme activities to the induction of toxic effects from inhalants such as benzo-a-pyrene, acetaminophen, formaldehyde, cocaine, dimethylnitrosamine, ferrocene, and 3-trifluoromethylpyridine have been the subject of dozens of reports. In addition, the influence of these enzyme activities on olfaction and their contribution to vapor uptake is beginning to receive attention from the research community. Research in the next decade promises to provide answers to the many still unanswered questions posed by the presence of the substantial xenobiotic metabolizing capacity of the nasal cavity.

Key Words:

• nasal
• cytochrome P-450
• xenobiotic metabolism
• olfactory tissue metabolism
• toxicity
• carcinogenicity
• olfaction