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Leukemia & Lymphoma Volume 52, 2011 - Issue 9
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Review

Follicular lymphoma: still Six characters in search of an author?

Pier Paolo PiccalugaHematopathology Section, Department of Hematology and Oncology ‘L. and A. Seràgnoli’, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
,
Stefano A. PileriHematopathology Section, Department of Hematology and Oncology ‘L. and A. Seràgnoli’, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, ItalyCorrespondence[email protected] [email protected]
,
Claudio AgostinelliHematopathology Section, Department of Hematology and Oncology ‘L. and A. Seràgnoli’, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
,
Wolfram KlapperDepartment of Pathology, Hematopathology Section and Lymph Node Registry, Christian-Albrechts-University, Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Germany
&
Karl LennertDepartment of Pathology, Hematopathology Section and Lymph Node Registry, Christian-Albrechts-University, Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Germany
Pages 1655-1667 | Received 12 Mar 2011, Accepted 15 Mar 2011, Published online: 10 Jun 2011
 
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Abstract

Follicular lymphoma (FL) is regarded as a distinct entity in the literature as well as in the 2008 edition of the WHO classification of tumours of haematopoietic and lymphoid tissues. Nevertheless, there are still several issues that are matters of controversy such as the grading system or the exact biological location of grade 3B FL. This makes FL somewhat like the Six characters in search of an author of Pirandello’s comedy. Here, we revise the morphology and pathobiology of FL by highlighting both the areas remaining critical and future perspectives. This review was inspired by the reappraisal of Professor Lennert’s personal archive that represents a unique legacy for the entire scientific community.

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