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Leukemia & Lymphoma Volume 53, 2012 - Issue 7
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Research Article

Functional polymorphisms in FAS, FASL and CASP8 genes and risk of childhood acute lymphoblastic leukemia: a case–control study

Na TongDepartment of Molecular and Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China;Department of Occupational Medicine and Environmental Health, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
,
Limei ZhangDepartment of Pediatrics, The Third Affiliated Hospital of Nanjing Medical University, Yizheng, China
,
Xiaojing ShengDepartment of Molecular and Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
,
Meilin WangDepartment of Molecular and Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China;Department of Occupational Medicine and Environmental Health, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
,
Zhizhong ZhangDepartment of Molecular and Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
,
Yongjun FangDepartment of Hematology and Oncology, The Affiliated Nanjing Children's Hospital of Nanjing Medical University, Nanjing, China
,
Yao XueDepartment of Molecular and Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
,
Jie LiDepartment of Hematology and Oncology, The Affiliated Children's Hospital of Soochow University, Suzhou, China
&
Zhengdong ZhangDepartment of Molecular and Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China;Department of Occupational Medicine and Environmental Health, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, ChinaCorrespondence[email protected]
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Pages 1360-1366 | Received 13 Dec 2011, Accepted 27 Dec 2011, Published online: 31 Jan 2012
 
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Abstract

Genetic polymorphisms in the promoter regions of FAS, FASL and CASP8 involved in the apoptotic signaling pathway are thought to be associated with susceptibility to cancer. We hypothesized that these functional genetic variants might be associated with the risk of childhood acute lymphoblastic leukemia (ALL). A case–control study in a Chinese population with 361 cases of ALL and 519 controls was performed to evaluate the association between FAS, FASL and CASP8 variants and risk of childhood ALL. Individuals with FAS − 1377AG had an odds ratio (OR) of 0.72 for the risk of ALL compared to − 1377GG and the variant FASL − 844CC was associated with a statistically significantly decreased risk of childhood ALL (OR = 0.38). Furthermore, combined genotypes with 5–8 protective alleles were associated with a significantly decreased risk of childhood ALL compared with those with 0–4 variants, and this decreased risk was more pronounced among the subgroups of age < 6 years, female, parental never-drinking status and never house-painting. Our results provide evidence that FAS–FASL–CASP8 polymorphisms contributed to a reduced risk of childhood ALL in our population. Larger studies are warranted to validate our findings.

Acknowledgements

This study was partly supported by the National Natural Science Foundation of China (30972444 and 81102089), the key program of the National Natural Science Foundation of Jiangsu Province (BK2010080), the National Natural Science Foundation of Jiangsu Province (BK2011775 and BK2011773), the Key Program for Basic Research of the Jiangsu Provincial Department of Education (08KJA330001 and 11KJB330002) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine).

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

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