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Leukemia & Lymphoma Volume 54, 2013 - Issue 7
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Research Articles

Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

Yasunori UedaDepartment of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, JapanCorrespondence[email protected]
,
Chisato MizutaniDepartment of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, Japan
,
Yasuhito NannyaDepartment of Hematology and Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Mineo KurokawaDepartment of Hematology and Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Sumiko KobayashiDepartment of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
,
Jin TakeuchiDepartment of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
,
Hideto TamuraDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
,
Kiyoyuki OgataDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
,
Kazuo DanDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
,
Hirohiko ShibayamaDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Yuzuru KanakuraDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Keiko NiimiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Ko SasakiDepartment of Hematology and Oncology, Dokkyo Medical University Hospital, Tochigi, Japan
,
Masato WatanabeDepartment of Hematology, Fujita Health University School of Medicine, Aichi, Japan
,
Nobuhiko EmiDepartment of Hematology, Fujita Health University School of Medicine, Aichi, Japan
,
Masanao TeramuraDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan
,
Toshiko MotojiDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan
,
Michiko KidaDivision of Hematology, NTT Kanto Medical Center, Tokyo, Japan
,
Kensuke UsukiDivision of Hematology, NTT Kanto Medical Center, Tokyo, Japan
,
Satoru TakadaDepartment of Hematology, Saiseikai Maebashi Hospital, Gunma, Japan
,
Toru SakuraDepartment of Hematology, Saiseikai Maebashi Hospital, Gunma, Japan
,
Yoshikazu ItoDivision of Hematology, Tokyo Medical University Hospital, Tokyo, Japan
,
Kazuma OhyashikiDivision of Hematology, Tokyo Medical University Hospital, Tokyo, Japan
,
Hiroyasu OgawaDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
,
Takahiro SuzukiDivision of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan
,
Keiya OzawaDivision of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan
,
Kiyotoshi ImaiDepartment of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
,
Masaharu KasaiDepartment of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
,
Tomoko HataDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
,
Yasushi MiyazakiDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
,
Yasuyoshi MoritaDivision of Hematology, Kinki University School of Medicine, Osaka, Japan
,
Akihisa KanamaruDivision of Hematology, Kinki University School of Medicine, Osaka, Japan
,
Akira MatsudaDepartment of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan
,
Kaoru TohyamaDepartment of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan
,
Daisuke KogaDiagnostic Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan
,
Hiroya TamakiDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
,
Kinuko MitaniDepartment of Hematology and Oncology, Dokkyo Medical University Hospital, Tochigi, Japan
,
Tomoki NaoeDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Haruo SugiyamaDepartment of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan
&
Fumimaro TakakuJichi Medical University, Tochigi, Japan
 show all
Pages 1450-1458 | Received 19 Aug 2012, Accepted 24 Oct 2012, Published online: 26 Nov 2012
 
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Abstract

A study to evaluate WT1 mRNA expression levels in peripheral blood (PB) and bone marrow aspirate (BM) was conducted in 172 patients, including 115 with myelodysplastic syndromes (MDS), in Japan. The level of WT1 mRNA expression was evaluated according to the French–American–British (FAB) and World Health Organization (WHO) classifications (2001, 2008) and using the International Prognostic Scoring System and the WHO Prognostic Scoring System scales. WT1 mRNA expression levels in PB and BM were well correlated (r = 0.85), and they tended to increase with disease stage progression and in those at higher risk of leukemic transformation. WT1 mRNA expression can be a useful marker for the diagnosis and risk evaluation of MDS.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

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