An upward trend in the age-specific incidence patterns for mantle cell lymphoma in the USA

Abstract

Although an increased incidence of mantle cell lymphoma (MCL) has been reported, age-specific incidence patterns have not been described. Further analyses could inform investigation into the etiology of this disease. We conducted an epidemiologic study using the 13 Surveillance, Epidemiology, and End Results (SEER) registries to evaluate MCL incidence from 1992 through 2009. We calculated the proportional changes in the incidence of MCL for subpopulations defined by age, race/ethnicity and gender over time and the racial/ethnic and gender disparities. We observed a 130.9% increase in MCL incidence from 1992–1994 to 2005–2009. The increase was strongest for males (199.0%) and for whites (153.0%). The incidence increased 161%, 200%, 398% and 429% from 1992–1994 to 2005–2009 in white men ages 50–59, 60–69, 70–79 and 80+, respectively, whereas the increase in white females was 86%, 82%, 50% and 193% in the corresponding age groups. We observed a male-to-female incidence rate ratio (IRR) of 2.65 and a white-to-black IRR of 2.21. Our analysis confirmed significant increases in MCL, and illustrated that the incidence is increasing more rapidly in elderly persons, particularly in white males. We also identified novel age-specific temporal trends by race/ethnicity and sex. In addition, we found that the gender and white-to-black disparities have grown over time. Our findings may impact MCL etiologic investigation and treatment research.

Keywords::

• Mantle cell lymphoma
• MCL
• incidence
• age-specific temporal trends
• gender
• racial disparities

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

This study was supported by grants CA94770 and CA100555 from the National Cancer Institute. The data set used for this analysis was obtained from the Surveillance, Epidemiology, and End Results (SEER) Program Public-Use Data (1973–2009), NCI, Department of Cancer Control and Population Sciences, Surveillance Research Program, Cancer Statistics Branch, released April 2012, based on the November 2011 submission of data by each of the registries. Dr Aschebrook-Kilfoy is supported by grant P3OCA14599.