10p12.31-12.2 variants and risk of childhood acute lymphoblastic leukemia in a Chinese population

Abstract

Acute lymphoblastic leukemia (ALL) is a clonal hematologic disease, and is the most common cause of childhood malignancy. Recently, a new locus was identified at 10p12.31-12.2 through a genome-wide association study (GWAS) that included racially and ethnically diverse populations. We conducted a replication study with 570 cases of ALL and 673 cancer-free controls to validated the association of this locus with ALL susceptibility in a Chinese population. The results of our study confirmed that the 10p12.31-12.2 locus was linked to childhood ALL susceptibility in the Chinese population. Interestingly, we also found that the single nucleotide polymorphisms (SNPs) in this locus had a larger effect on susceptibility to high-risk ALL than on susceptibility to low-risk ALL.

Keywords::

• 10p12.31-12.2
• risk
• childhood ALL
• verification

Acknowledgements

We thank Heng Xu and Jun J. Yang from St. Jude Children's Research Hospital for their generous support. We also thank the National Natural Science Foundation of China (81070436) and Nanjing Special Foundation of Medical Sciences for their support.

Potential conflict of interest

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