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Abstract
A multi-center retrospective analysis of a cohort of patients in Israel treated with any bendamustine containing regimen between 2010–2014 was performed in order to determine the incidence and predictors for infection. The Kaplan Meier Model, employing log rank analysis, was used to assess time-to-infection. The Cox Proportional Hazards model was used to analyze multivariate effects of risk and 234 patients were included in the analysis. One hundred and nine (46.6%) developed at least one infection and 33.76% had severe infections. Seventy-six (41.5%) developed bacterial infection, nine (3.8%) fungal infection and 26 (11.5%) had viral infections. Factors significantly associated with time to infection on multivariable analysis were: bendamustine-combinations [hazard ratio (HR) = 0.589 (95% CI = 0.374–0.926), p = 0.022], Hb level [HR = 0.791 (95% CI = 0.716–0.875), p < 0.0001] and ischemic heart disease [HR = 1.828 (95% CI = 1.165–2.868), p = 0.009]. Infections were associated with a higher mortality and hospitalization rate.
Potential conflict of interest
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