Total body-surface area as a new prognostic variable in mycosis fungoides and Sézary syndrome

Abstract

Mycosis fungoides and Sézary syndrome (MF/SS) are the most common forms of primary cutaneous T cell lymphomas. We analyzed the applicability of the cutaneous lymphoma international prognostic index (CLIPi) in MF/SS. We introduced the total body-surface area affected (TBSA) and the type of skin lesions at diagnosis as prognostic variables. The overall survival (OS) at median time of follow up (96 months) was 75.6% (CI 95%, 62.0–98.5%). In the univariate analysis, age >60 years, advanced disease, type of skin lesions and TBSA >50 showed poorer OS (p < 0.05). In the multivariate analysis there was a significant increased relative risk of death in those patients >60 years, with advanced disease and TBSA >50% (p < 0.05). TBSA identified a group of poor prognosis patients with advanced MF/SS that may benefit from novel systemic therapies.

Keywords:

• CLIPi
• cutaneous T-cell lymphoma
• mycosis fungoides
• prognosis
• Sézary syndrome

Acknowledgements

Supported in part by grants AGAUR 2014SGR-1281 and ISCIII RD12/0036/0071 and a grant from Cellex Research Foundation, Barcelona, Spain. We want to thank very especially Ana C. Caballero for her work in data collection and Rodrigo Martino for his suggestions in data analysis.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.3109/10428194.2015.1057894.