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Abstract
The application of high throughput surface characterization (HTSC) to the analysis of polymeric biomaterial libraries is an important advancement for the discovery and development of new biomedical materials and is the focus of this review. The potential for HTSC to identify structure/activity relationships for large libraries of materials can be utilized to accelerate materials discovery as well as providing insight into the underlying biological-material interactions. Furthermore, the correlations identified between surface chemical structure and cellular behavior could not have been predicted by a rational design approach based simply on review of bulk structure, which demonstrates the importance of HTSC in the assessment of cell-material and cell-biomolecular interactions that are dependent on surface properties.
Acknowledgement
R.L. and M.C.D. would like to acknowledge the contribution of Bob Davis, albeit he would say unwittingly, in the development of the work described in this review. In the mid 1980s, Bob appointed M.C.D. to the faculty at Nottingham and encouraged him to pursue his surface analysis work and specifically, recommended that he contact RL to collaborate. Many years and a number of publications later, this collaboration now including D.G.A. and M.R.A. lead with the help of some very bright young postdoctoral and postgraduate scientists, to the advent of high throughput surface analysis of polymeric arrays. In addition, R.L., M.C.D. and all the authors would also like to acknowledge the outstanding world-leading international research of Bob Davis in the pharmaceutical sciences and in particular in advanced drug delivery research.
Declaration of interest
The authors report no declarations of interest.