Recent developments in ocular drug delivery

Abstract

Ocular drug delivery has many challenges due to the inherent physiology and natural barriers. Traditionally used eye drops are fairly inefficient with low ocular bioavailability, and drug delivery to the back of the eye currently requires invasive measures, such as implants or frequent intravitreal injections. These challenges, however, present unique opportunities for innovative drug delivery approaches. This review highlights several of these approaches, with special emphasis on those progressing in clinical development.

• Cell and gene therapy
• contact lens
• implants
• iontophoresis
• particulates
• posterior
• punctal plug
• topical inserts

Declaration of interest

The author is a current employee of Kala Pharmaceuticals, Inc.

Notes

* This manuscript is submitted for inclusion in the JDT lifetime Achievement Award issue for Prof Robert Langer