Abstract
Objectives. We hypothesized that hydrogen peroxide (H2O2) and soluble TNF-α receptor 2 (sTNF-R2) co-play a role in the pathogenesis of preeclampsia. Methods. Correlation of H2O2 and sTNF-R2 was assessed in vivo in maternal blood and placenta, and in vitro in cytotrophoblasts culture. Results. We showed a positive correlation between increased levels of H2O2 and sTNF-R2 early at 10–15 gestational weeks and at term in maternal serum, and in placenta of women with preeclampsia. Our in vitro experiments showed that H2O2 induced the placental synthesis of sTNF-R2. Conclusion. We propose to consider H2O2 and sTNF-R2 as potential biomarkers in predicting preeclampsia.
ACKNOWLEDGMENT
The authors thank Danielle Beaulieu and Josée Poulin for recruitment of patients, collection of samples, and providing clinical data. This study was supported by funding provided by the Fondation des étoiles (FE), the Fonds de Recherche en Santé du Québec (FRSQ), the Canadian Instituts of Health Research (CIHR), and the Centre de Recherche Clinique (CRC)-Étienne-Lebel du CHUS.
Declaration of Interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.