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Hypertension in Pregnancy Volume 32, 2013 - Issue 3
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Research Article

Oxidative stress and immunological alteration in women with preeclampsia

Danilla Michelle Costa e SilvaNutrition Department, Federal University of Piauí TeresinaBrazil
,
Dilina do Nascimento MarreiroNutrition Department, Federal University of Piauí TeresinaBrazil
,
José Machado Moita NetoChemistry Department, Federal University of Piauí TeresinaBrazil
,
José Araújo BritoMaternal and Child Health Department, Federal University of Piauí TeresinaBrazil
,
Eunice Alves da Silva NetaNutrition Department, Federal University of Piauí TeresinaBrazil
,
Juliana Paz MatiasNutrition Department, Federal University of Piauí TeresinaBrazil
,
Fabiane Araújo SampaioNutrition Department, Federal University of Piauí TeresinaBrazil
&
Nadir do Nascimento NogueiraNutrition Department, Federal University of Piauí TeresinaBrazilCorrespondence[email protected]
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Pages 304-311 | Received 23 Nov 2012, Accepted 04 May 2013, Published online: 01 Aug 2013
 
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Abstract

Objectives: To determine plasma concentrations of malondialdehyde (MDA) and of inflammatory markers in women with preeclampsia. Methods: A case–control study was conducted on 50 preeclamptic and 50 healthy pregnant women. The concentrations of MDA were determined by the method of thiobarbituric acid reactive substances. Markers of inflammation were determined by the multiplex method. Results: The concentrations of MDA did not differ between groups (p > 0.05) and the preeclampsia group had significantly higher IL-6, IL-10, TNF-α and IL-6/IL-10 ratio, compared to those with normal pregnancy. Conclusions: The MDA is a nonspecific marker for oxidative stress in preeclampsia, and the gestantes with preeclampsia have immune dysfunction.

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