LPL Ser447Ter and Asn291Ser variants in Romanians: associations with preeclampsia – implications on lipid profile and prognosis

Abstract

Objectives: To investigate the role of LPL-Ser447Ter and Asn291Ser polymorphisms in the predisposition to different types of preeclampsia, as well as the contribution to the lipid profile and the prognosis of preeclampsia. Methods: 125 women with preeclampsia and 131 normal pregnant women were genetically screened using PCR-restriction enzyme analysis. Results: We found an increased risk for mild and severe preeclampsia in carriers of the negative Ser447/Ser447 genotype. An increased risk for severe preeclampsia in carriers of the Asn291Ser polymorphism was seen. In mild and severe preeclampsia, carriers of the negative Ser447/Ser447 genotype had increased TG and LDL-C levels and decreased HDL-C levels as compared with carriers of the Ser447Ter polymorphism. The presence of the Asn291Ser polymorphism influenced the higher TG and LDL-C levels and the lower HDL-C levels in mild preeclampsia and the higher TG and LDL-C levels in severe preeclampsia. Women with severe preeclampsia, carriers of the Ser447/Ser447 genotype and women with mild preeclampsia, carriers of the Asn291Ser polymorphism, delivered at a lower gestational age neonates with a lower birth weight compared to women carriers of this polymorphism. Conclusions: The LPL variants are associated with severe preeclampsia and influence the lipid profile and pregnancy outcome in mild and severe preeclampsia.

• Lipoproteins
• Ser447Ter
• Asn291Ser
• PCR-RFLP
• Lipid profile
• Preeclampsia

Acknowledgements

We thank Mrs Denisa Marineanu at the “Iuliu Hatieganu” University of Medicine and Pharmacy for English expertise. We also thank Mrs Teodora Mocanu at the “Iuliu Hatieganu” University of Medicine and Pharmacy for the statistical analysis of the data.