The effects of gene polymorphisms in angiotensin II receptors on pregnancy-induced hypertension and preeclampsia: a systematic review and meta-analysis

Abstract

Background: To assess whether the polymorphisms of angiotensin II type 1 and type 2 receptors (AT1R, AT2R) are associated with pregnancy-induced hypertension (PIH) and preeclampsia. Methods: Studies were searched from PubMed, ISI Web of Science and HuGE Navigator. Results: The A1166C polymorphism of AT1R, A1675G and C3123A polymorphisms of AT2R were analyzed. Significant association was found in recessive model (OR = 1.581, 95% confidence interval (CI): 1.054–2.371) and co-dominant (GG versus AG) model (OR = 1.900, 95%CI: 1.001–3.604) between the A1675G polymorphism and preeclampsia. No association was found between the other polymorphisms and PIH or preeclampsia. Conclusions: The A1675G polymorphism might be associated with preeclampsia, but the A1166C and C3123A polymorphisms had no effect on PIH or preeclampsia.

• Angiotensin II receptors
• Genetics
• Meta-analysis
• Preeclampsia
• Pregnancy-induced hypertension (PIH).

DECLARATION OF INTEREST

This work was supported by grant from the National Natural Science Foundation of China (grant number: 81172679/H2605). Yingxue Li, Ming Zhu, Rong Hu and Weirong Yan certify that no actual or potential conflict of interest in relation to this article exists.