Genistein attenuates oxidative damage in preeclamptic placental trophoblast

ABSTRACT

Objective: To evaluate the effect of genistein supplementation on the oxidative/nitrative stress and antioxidant capacity of normotensive and preeclamptic placental trophoblast. Methods: The stress status of placental trophoblast was assessed by measuring their respective markers before and after incubation with genistein. Results: A significant increase in stress along with decrease in antioxidant status was observed in preeclamptic placental trophoblast, whereas genistein incubation significantly alters oxidant-antioxidant status. Conclusion: The study revealed that genistein may play a significant role in controlling oxidative/nitrative stress during preeclampsia. Hence, genistein can be used as an effective dietary supplement for the treatment and management of preeclampsia.

KEYWORDS:

• Antioxidant
• estrogen
• genistein
• preeclampsia
• stress
• trophoblast

Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.