Plasma Apelin and ADMA Levels in Patients with Essential Hypertension

Abstract

Both apelin and asymetric dymethyl arginine (ADMA) regulate blood pressures. Low apelin and high ADMA levels have been reported in several cardiometabolic disorders. However, there is no data about ADMA and apelin levels in essential hypertension and any relationship between them. We investigated a group of newly diagnosed and untreated 30 young hypertensive men and 30 healthy controls. Apelin levels were significantly lower and the ADMA levels were significantly higher in the patients (p = 0.04 for both). Both ADMA and apelin were related to the systolic blood pressures (SBP) (beta = −0.393, p = 0.003; beta = 0.285, p = 0.03, respectively). Future studies are necessary in order to clearly define the role of ADMA and apelin in the pathogenesis of essential hypertension.

Keywords:

• apelin
• asymetric dymethyl arginine (ADMA)
• essential hypertension

Acknowledgment

The authors wish to thank to Laboratory Technician Halil Oguz for his painstaking efforts on the allocation and preservation of the serum samples. The study was supported by GATA Research Center (AR-2004/86).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.