Effect of Early Diabetes on the Response to Norepinephrine and Dopamine in Pithed Wistar Kyoto and Spontaneously Hypertensive Rats

Abstract

Diabetes has been related to changes in vascular responses, mainly an increase in the vasoconstrictor responses and a decrease in the vasodilator responses. The literature has now begun to study the effects of diabetes in the early stages of development; the first studies on these stages indicate that diabetes produces different changes compared to the advanced stages. For that reason, the aim of this work was to evaluate the responses to norepinephrine and dopamine on normotensive and hypertensive rats with 4 weeks of diabetes evolution. The results showed that 4 weeks of diabetes produces a decrease of the vasopressor response to both agents (norepinephrine and dopamine). These results suggest that in the early stages, there are changes that help to decrease the pressor responses and these changes could disappear in the advanced stages.

Keywords:

• norepinephrine
• dopamine
• diabetes
• hypertension
• vasopressor

ACKNOWLEDGMENTS

This research was supported by grant 20080324 from Instituto Politécnico Nacional and grant 82599 from CONACYT.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.