Effect of Endurance Exercise Training on Oxidative Stress in Spontaneously Hypertensive Rats (SHR) After Emergence of Hypertension

Abstract

The purpose of this study is to elucidate the effect of wheel training on oxidative stress maker levels in spontaneous hypertensive rats (SHR). 4-hydroxynonenal and 3-nitrotyrosine levels in the aorta of SHRs were allowed to run for 10 weeks from the age of 15 weeks were measured and compared with those of nonexercised SHRs. The 4-hydroxynonenal and 3-nitrotyrosine levels in the exercised group were significantly lower than those in the nonexercised group. The exercised group showed a significant increase of manganese-containing superoxide dismutase. Endurance exercise showed a possible suppressing effect on the arteriosclerosis development by reducing oxidative stress, even after emergence of hypertension.

• spontaneously hypertensive rat (SHR)
• exercise training
• 4-hydroxynonenal
• 3-nitrotyrosine
• time-resolved fluoroimmunoassay
• superoxide dismutase

ACKNOWLEDGMENTS

This work has been supported by a grant-in-aid for scientific research no. 18590644, 21590743, and 18500514 from the Ministry of Education, Culture, Sports and Technology and also supported by High-Tech Research Center Project for Private Universities; matching fund subsidy from the Ministry of Education, Culture, Sports, Science and Technology, Japan.