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Clinical and Experimental Hypertension Volume 34, 2012 - Issue 7
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Research Article

A Bedtime Dose of ARB Was Better than a Morning Dose in Improving Baroreflex Sensitivity and Urinary Albumin Excretion—The J-TOP Study

Kazuo EguchiDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, JapanCorrespondence[email protected]
,
Motohiro ShimizuDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
,
Satoshi HoshideDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
,
Kazuyuki ShimadaDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
&
Kazuomi KarioDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
Pages 488-492 | Received 24 Oct 2011, Accepted 21 Dec 2011, Published online: 25 Apr 2012
 
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Abstract

The hypothesis that the bedtime dosing of angiotensin receptor blocker (ARB) is superior to morning dose in improving baroreflex sensitivity (BRS) and urinary albumin/creatinine ratio (UACR) was tested in this study. Baroreflex sensitivity was measured at baseline and at 6th month (N = 109) and was found to increase in the bedtime-dose group (P = .004), but not in the morning-dose group. The correlations between the change in BRS and the change in UACR were insignificant in the morning-dose group (r = 0.17, P = .26), but were significant in the bedtime-dose group (r = –0.29, P = .04). In conclusion, the improvement of BRS could be one of the mechanisms by which bedtime dosing of ARB confers renal protection.

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