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Clinical and Experimental Hypertension Volume 35, 2013 - Issue 1
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Research Article

Basal and Postprandial Serum Levels of Gastrin in Normotensive and Hypertensive Adults

Xiaoliang JiangKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, PR China
,
Wenjie WangKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, PR China
,
Bin NingFuyang People’s Hospital, Fu Yang City, An Hui Province, PR China
,
Xing LiuKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, PR China
,
Jian GongFuyang People’s Hospital, Fu Yang City, An Hui Province, PR China
,
Fusheng GanFuyang People’s Hospital, Fu Yang City, An Hui Province, PR China
,
Xuezhong GaoFuyang People’s Hospital, Fu Yang City, An Hui Province, PR China
,
Lianfeng ZhangKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, PR China
,
Pedro A. JoseDivision of Nephrology, Department of Medicine, University of Maryland Medical Center, Baltimore, MD, USA
,
Chuan QinKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, PR China
&
Zhiwei YangKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical College (PUMC), Beijing, PR ChinaCorrespondence[email protected]
 show all
Pages 74-78 | Received 30 Mar 2012, Accepted 27 Apr 2012, Published online: 08 Jun 2012
 
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Abstract

Gastrin is a peptide hormone, which acts not only to regulate gastric acid secretion, but also to exert physiological actions such as the regulation of sodium balance. From a case (n = 95)–control (n = 82) study in Fuyang People’s Hospital, Anhui Province, China, we found that the fasting serum gastrin levels are similar in normotensive and hypertensive adults but increased to higher levels in the latter group than in the former group after a mixed meal. We suggest that gastrin is involved in the regulation of blood pressure, possibly via the regulation of sodium and water metabolism and/or renin–angiotensin–aldosterone system. However, the mechanism remains to be determined.

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