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Clinical and Experimental Hypertension Volume 35, 2013 - Issue 5
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Research Articles

Improving Drug Adherence Using Fixed Combinations Caused Beneficial Treatment Outcomes and Decreased Health-Care Costs in Patients with Hypertension

Naoto KumagaiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
,
Katsuya OnishiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, JapanCorrespondence[email protected]
,
Kozo HoshinoDepartment of Cardiology, Nagai Hospital, Tsu, Mie, Japan
,
Shiro NakamoriDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
,
Tamaki KitaiHeartful Clinic Kitai, Suzuka, Mie, Japan
,
Takahiro YazuYazu Naika Clinic, Matsusaka, Mie, Japan
,
Masahiro OotaOota Clinic, Komono, Mie, Japan
,
Yuji UedaUeda Clinic, Suzuka, Mie, Japan
,
Naoto HiraokaHiraoka Clinic, Matsusaka, Mie, Japan
,
Shinya OkamotoDepartment of Internal Medicine, Iwasaki Hospital, Tsu, Mie, Japan
,
Tomomi YamadaDepartment of Translational Medical Science, Mie University Graduate School of Medicine, Tsu, Mie, Japan
,
Kaoru DohiDepartment of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
,
Mashio NakamuraDepartment of Clinical Cardiovascular Research, Mie University Graduate School of Medicine, Tsu, Mie, Japan
&
Masaaki ItoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
 show all
Pages 355-360 | Received 10 Jul 2012, Accepted 29 Aug 2012, Published online: 16 Oct 2012
 
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Abstract

We enrolled 196 patients with hypertension who were already being treated with free-drug combinations of angiotensin-II receptor blocker (ARB) and amlodipine. The free-drug combinations of ARB and amlodipine were replaced with the same dose of the fixed-dose combinations. The average home blood pressure (BP) in all patients receiving fixed-dose combinations was significantly lower than those receiving free-drug combinations (131 ± 10/75 ± 8 vs. 136 ± 11/77 ± 9 mm Hg, P < .01) accompanied with increasing drug adherence. After lowering BP by fixed-dose combinations, the costs for medications decreased by 31% over the 3 months.

ACKNOWLEDGMENT

We would like to convey our special thanks to Mrs. Tomoko Moriyama for technical support.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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