Associations Between Visit-to-visit Variability in Blood Pressure Measured in the Office and Antihypertensive Drugs: The J-HOME-Morning Study

Abstract

The factors associated with visit-to-visit variability in blood pressure (BP) measured in the office between the two visits were identified in 1379 treated hypertensive patients (mean age, 66.1 ± 11.0 y; women, 53.8%). Multivariate regression analysis showed that office BP and visit-to-visit heart rate variability were positively associated with visit-to-visit BP variability, whereas body mass index, duration of antihypertensive medication, and taking amlodipine were negatively associated with visit-to-visit BP variability. Further prospective studies are required to clarify the causal relationships between these factors and visit-to-visit BP variability among treated hypertensive patients.

• hypertension
• blood pressure variability
• office blood pressure measurement
• antihypertensive drugs
• cross-sectional study

ACKNOWLEDGEMENTS

The investigators designed and conducted the study and interpreted the findings independently of the sponsors. This study was based on data collected by the J-HOME-Morning study group.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This study was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology, by Junkanki-Byou-Itaku-Kenkyuhi (H19-Kou-8) from the National Cardiovascular Center, and funding from Nouvelle Place Inc., Japan.