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Abstract
9α-Fluorocortisol (9αFF) is an analogue of Cortisol with ‘mineralocorticoid’, ‘glucocorticoid’ and ‘hypertensinogenic’ activity. 9αFF was infused at 2 mg/day for 5 days to sheep receiving a normal Na intake (100 mmol/d) and a high K intake (=800 mmol/d). K loading modified the Na retaining effects of 9αFF but had no effect on the development of the hypertension. These experiments suggest that the effects of K loading on the development of 9α-FF hypertension are not related simply to the effects that K has on modifying the Na retaining effects of the steroid.