Carbonyl groups: Bridging the gap between sleep disordered breathing and coronary artery disease

Abstract

Sleep disordered breathing (SDB) is related to coronary artery disease (CAD), but the mechanisms are uncertain. SDB is characterized by periods of intermittent hypoxia and free radical formation. This study tested the hypothesis that carbonylation can be the link between SDB and CAD. It included 14 cases with CAD and 33 controls with <50% coronary narrowing. CAD cases have higher erythrocyte carbonyl levels than controls (p = 0.012). Positive correlation was observed between apnea-hypopnea index (AHI) and erythrocyte carbonyl concentration (ρ = 0.310; p = 0.027). To predict CAD, including as regressors: AHI, erythrocyte carbonyl, gender, age and body mass index, the significant variables in the Poisson multiple regression model were AHI and erythrocytes carbonyl. An increase of 1 pmol/gHb in erythrocyte carbonyl levels increases by 1.8% the risk of CAD and one unit of AHI increases by 3.8% the risk of CAD. The present findings represent the first evidence in humans that SDB may cause CAD through protein carbonylation.

Keywords::

• Sleep apnea
• coronary artery disease
• oxidative stress
• carbonyl

Declaration of interest: This study received grants from the Brazilian Government through Fundo de Incentivo à Pesquisa do Hospital de Clinicas de Porto Alegre (FIPE – HCPA), Conselho Nacional de Desenvolvimento científico e Tecnológico (CNPq), Fundação de Amparo e Pesquisa do Rio Grande do Sul (Fapergs). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.